Reaction: PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
The histone arginine methyltransferase PRMT6 asymmetrically dimethylates histone H3 on arginine residue R2 (R3 when taking into account the initiator methionine), thus creating the H3R2me2a mark on nucleosomes at the THBS1 gene promoter. Histone H3 arginine methylation by PRMT6 interferes with generation of the activating H3K4me3 mark at the THBS1 gene promoter, thus contributing to transcriptional repression (Michaud-Levesque and Richard 2009).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-8937022
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-8937022