Reaction: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
- in pathway: FRS-mediated FGFR2 signaling
RAS nucleotide is stimulated downstream of activated FGFR2 in a p-PTPN11-dependent manner. The phosphatase activity of PTPN11 is required for activation of the RAS-MAP kinase pathway, although the mechanism for RAS pathway activation is not yet clear (Hadari et al, 1998; reviewed in Mohi et al, 2007; Gotoh et al, 2008).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-8941618
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-8941618