Reaction: Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
- in pathway: Cholesterol biosynthesis
Phospholipid phosphatase 6 (PLPP6) dephosphorylates presqualene diphosphate (PSQPP) to presqualene monophosphate (PSMP). It may be indirectly involved in innate immunity, as PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. PLPP6 displays diphosphate phosphatase activity with a substrate preference PSDP > FDP > phosphatidic acid.
Reaction - small molecule participants:
presqualene monophosphate [cytosol]
Pi [cytosol]
H2O [cytosol]
PSQPP [cytosol]
Reactome.org reaction link: R-HSA-8952137
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Reaction input - small molecules:
water
presqualene diphosphate
Reaction output - small molecules:
presqualene monophosphate
hydrogenphosphate
Reactome.org link: R-HSA-8952137