Reaction: LRTOMT transfers Met to DA, forming 3MT
- in pathway: Enzymatic degradation of dopamine by COMT
Transmembrane O-methyltransferase (LRTOMT aka COMT2) catalyses the O-methylation of catecholamine neurotransmitters, thereby inactivating them (Du et al. 2008). LRTOMT is highly expressed in sensory hair cells of the inner ear. Defects in LRTOMT can cause autosomal recessive deafness 63 (DFNB63), a form of non-syndromic sensorineural hearing loss (Ahmed et al. 2008, Du et al. 2008). In this example, dopamine (DA) is O-methylated using S-adenosyl-L-methionine (AdoMet) as the methyl donor to form 3-methyltyramine (3MT) and S-adenosyl-L-homocysteine (AdoHcy).
Reaction - small molecule participants:
3MT [cytosol]
AdoHcy [cytosol]
AdoMet [cytosol]
DA [cytosol]
Reactome.org reaction link: R-HSA-8955010
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
dopaminium(1+)
Reaction output - small molecules:
3-methoxytyramine
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-8955010