Reaction: MECP2 is phosphorylated at T308
- in pathway: Regulation of MECP2 expression and activity
Calcium-dependent protein kinases, PKA and CaMK IV, activated by neuronal membrane depolarization, phosphorylate MECP2 at threonine residue T308. Only the PKA C-alpha isoform (PRKACA) was experimentally tested. T308 corresponds to T320 in the longer MECP2 splicing isoform, MECP2_e1 (MECP2B). Phosphorylation of MECP2 at threonine residue T308 is correlated with neuronal activity and inhibits binding of MECP2 to the nuclear receptor co-repressor complex (NCoR/SMRT) (Ebert et al. 2013).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-8986937
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8986937