Reaction: SLITs bind keratan sulfate
- in pathway: Signaling by ROBO receptors
SLIT2 is expressed by corneal epithelial cells and able to bind to keratan sulfate, which is part of the corneal stroma extracellular matrix. This interaction may influence corneal nerve growth cone penetration. SLIT3 may also interact with keratan sulfate, as well as ROBO receptors ROBO1 and ROBO2 (Conrad et al. 2010).
Reaction - small molecule participants:
Keratan sulfate [extracellular region]
Reactome.org reaction link: R-HSA-9010815
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Reaction input - small molecules:
keratan sulfate
Reaction output - small molecules:
Reactome.org link: R-HSA-9010815