Meta-Biol

• Pathways

The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC2 and catalyze GDP to GTP exchange on RAC2, resulting in formation of the active RAC2:GTP complex:
ABR (Chuang et al. 1995)
BCR (Chuang et al. 1995)
DEF6 (Mavrakis et al. 2004)
DOCK2 (Sai et al. 2008; Kwofie and Skowronski 2008 )
MCF2 (Jaiswal et al. 2013)
PREX1 (Welch et al. 2005; Dong et al. 2005; Barber et al. 2007; Jaiswal et al. 2013)
TIAM1 (Haeusler et al. 2003; Niebel et al. 2013; Jaiswal et al. 2013)
TRIO (Newsome et al. 2000; Hakeda-Suzuki et al. 2002; Jaiswal et al. 2013)
VAV1 (Ming et al. 2007; Miletic et al. 2007; Yin et al. 2011)
VAV2 (Arana et al. 2008; Jaiswal et al. 2013)
VAV3 (Flannagan et al. 2014)

The following GEFs are annotated as candidate RAC2 GEFs since they were shown to bind RAC2, but their ability to activate RAC2 has not been tested:
DOCK1 (Kwofie and Skowronski 2008)
DOCK3 (Kwofie and Skowronski 2008)
DOCK4 (Kwofie and Skowronski 2008)
DOCK10 (Ruiz-Lafuente et al. 2015)
SWAP70 (Sivalenka and Jessberger 2004)

The following RHO GEFs do not act on RAC2:
ARHGEF1 (Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2013)
ARHGEF28 (Jaiswal et al. 2013)
ARHGEF4 (Gotthardt and Ahmadian 2007; Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
DOCK9: (Kwofie and Skowronski 2008)
DOCK11 (Ruiz-Lafuente et al. 2015)
ITSN1 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
PLEKHG5 (De Toledo et al. 2001)