Meta-Biol

• Pathways

The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOG and catalyze GDP to GTP exchange on RHOG, resulting in formation of the active RHOG:GTP complex:
ITSN1 (Jaiswal et al. 2013)
KALRN (May et al. 2002)
MCF2 (Zheng et al. 1995; Movilla and Bustelo 1999)
PREX1 (Damoulakis et al. 2014; Jaiswal et al. 2013)
TRIO (Blangy et al. 2000; Estrach et al. 2002; Peurois et al. 2017; Jaiswal et al. 2013; supported by interaction of TRIO with inactive RHOG mutant reported by Bagci et al. 2020)
VAV1 (Schuebel et al. 1998)
VAV3 (Movilla and Bustelo 1999)

The following GEFs, annotated as RHOG candidate GEFs, were shown to activate RHOG in some, but not all studies:
ARHGEF16 (Hiramoto Yamaki et al. 2010; Harada et al. 2011: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
ARHGEF26 (Ellerbroek et al. 2004: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
ARHGEF5 (Wang et al. 2009: weak RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
MCF2L (Wennerberg et al. 2002; Jaiswal et al. 2013: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
VAV2 (Schuebel et al. 1998; Wennerberg et al. 2002; Jaiswal et al. 2013: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)

The following GEFs were shown to either not act on RHOG or to not bind to inactive RHOG mutant in the high throughput screen by Bagci et al. 2020:
AKAP13 (Bagci et al. 2020)
ARHGEF1 (Bagci et al. 2020)
ARHGEF11 (Jaiswal et al. 2013; Bagci et al. 2020)
ARHGEF12 (Jaiswal et al. 2013; Bagci et al. 2020)
ARHGEF17 (Bagci et al. 2020)
ARHGEF2 (Bagci et al. 2020)
ARHGEF28 (Jaiswal et al. 2013)
ARHGEF3 (Arthur et al. 2002)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF40 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
ARHGEF9 (Jaiswal et al. 2013)
BCR (Bagci et al. 2020)
DNMBP (Jaiswal et al. 2013; Bagci et al. 2020)
DOCK6 (Bagci et al. 2020)
DOCK7 (Bagci et al. 2020)
DOCK8 (Bagci et al. 2020)
DOCK9 (Ruiz Lafuente et al. 2015; Bagci et al. 2020)
DOCK10 (Ruiz Lafuente et al. 2015)
DOCK11 (Ruiz Lafuente et al. 2015; Bagci et al. 2020)
ECT2 (Bagci et al. 2020)
FARP1 (Bagci et al. 2020)
NGEF (Bagci et al. 2020)
PLEKHG2 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
PLEKHG5 (De Toledo et al. 2001)
SWAP70 (Bagci et al. 2020)
TIAM1 (Jaiswal et al. 2013; Bagci et al. 2020)