Reaction: RHOBTB2 binds GTP
- in pathway: RHOBTB2 GTPase cycle
RHOBTB2 binds to GTP, but does not switch between GDP- and GTP-bound states (Manjarrez et al. 2014). ATP-dependent protein folding chaperone activity of the HSP90:CDC37 complex and binding of RHOBTB2 to the HSP90:CDC37 complex enables RHOBTB2 to bind GTP (Manjarrez et al. 2014). There are no known RHOBTB2 GAPs - DEBDC1B was reported to bind RHOBTB2 by Bagci et al. 2020, but its RHOBTB2-directed GAP activity has not been tested.
Reaction - small molecule participants:
GTP [cytosol]
Reactome.org reaction link: R-HSA-9018785
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-9018785