Reaction: RAC3 GEFs activate RAC3
- in pathway: RAC3 GTPase cycle
The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC3 and catalyze GDP to GTP exchange on RAC3, resulting in formation of the active RAC3:GTP complex:
MCF2 (Jaiswal et al. 2013)
PREX1 (Waters et al. 2008; Jaiswal et al. 2013)
TIAM1 (Haeusler et al. 2003)
TRIO (Jaiswal et al. 2013)
VAV2 (Rosenberg et al. 2017; Jaiswal et al. 2013)
DOCK10 is annotated as a candidate RAC3 GEF, because it binds to RAC3 but its ability to activate RAC3 is uncertain (Ruiz-Lafuente et al. 2015).
The following GEFs do not act on RAC3:
DOCK11 (Ruiz-Lafuente et al. 2015)
ITSN1 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
PLEKHG5 (De Toledo et al. 2001)
MCF2 (Jaiswal et al. 2013)
PREX1 (Waters et al. 2008; Jaiswal et al. 2013)
TIAM1 (Haeusler et al. 2003)
TRIO (Jaiswal et al. 2013)
VAV2 (Rosenberg et al. 2017; Jaiswal et al. 2013)
DOCK10 is annotated as a candidate RAC3 GEF, because it binds to RAC3 but its ability to activate RAC3 is uncertain (Ruiz-Lafuente et al. 2015).
The following GEFs do not act on RAC3:
DOCK11 (Ruiz-Lafuente et al. 2015)
ITSN1 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
PLEKHG5 (De Toledo et al. 2001)
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9018804
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9018804