Reaction: RHOT1 GEFs activate RHOT1
- in pathway: RHOT1 GTPase cycle
Based on studies in Drosophila, RAP1GDS1, an orthologue of Drosophila Vimar, is a mitochondrial outer membrane-bound atypical guanine nucleotide exchange factor (GEF) that activates mitochondria-associated atypical RHO GTPase RHOT1, an orthologue of Drosophila Miro, by catalyzing GDP to GTP exchange, resulting in formation of the active RHOT1:GTP complex (Ding et al. 2016).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9018817
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9018817