Reaction: RHOT2 GEFs activate RHOT2
- in pathway: RHOT2 GTPase cycle
Based on studies in Drosophila, RAP1GDS1, an orthologue of Drosophila Vimar, is a mitochondrial outer membrane-bound atypical guanine nucleotide exchange factor (GEF) that activates mitochondria-associated atypical RHO GTPase RHOT2, an orthologue of Drosophila Miro, by catalyzing GDP to GTP exchange, resulting in formation of the active RHOT2:GTP complex (Ding et al. 2016).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9018825
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9018825