Reaction: 5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2
- in pathway: Biosynthesis of E-series 18(S)-resolvins
An unknown dehydrogenase reduces 5(S)-hydroperoxy-18(S)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(S)-HEPE) into the 18(S) stereoisomer of resolvin E2 (18(S)-RvE2). The unknown enzyme may be 5-hydroxyeicosanoid dehydrogenase (5-HEDH) or one similar to this (Patel et al. 2009). Human neutrophils biosynthesise RvE2 in greater amounts than RvE1, suggesting a significant role for RvE2 (Tjonahen et al. 2006, Oh et al. 2012).
Reaction - small molecule participants:
NADP+ [cytosol]
18(S)-RvE2 [cytosol]
NADPH [cytosol]
5(S)-Hp-18(S)-HEPE [cytosol]
Reactome.org reaction link: R-HSA-9018867
======
Reaction input - small molecules:
NADPH(4-)
(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoic acid
Reaction output - small molecules:
NADP(3-)
(18S)-resolvin E2
Reactome.org link: R-HSA-9018867