Reaction: 5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2
- in pathway: Biosynthesis of E-series 18(R)-resolvins
An unknown dehydrogenase reduces 5(S)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(R)-HEPE) into the 18(R) stereoisomer of resolvin E2 (18(R)-RvE2). The unknown enzyme may be 5-hydroxyeicosanoid dehydrogenase (5-HEDH) or one similar to this (Patel et al. 2009). Human neutrophils biosynthesise RvE2 in greater amounts than RvE1, suggesting a significant role for RvE2 (Tjonahen et al. 2006, Oh et al. 2012).
Reaction - small molecule participants:
18(R)-RvE2 [cytosol]
NADP+ [cytosol]
5(S)-Hp-18(R)-HEPE [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-9018901
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Reaction input - small molecules:
5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoic acid
NADPH(4-)
Reaction output - small molecules:
resolvin E2
NADP(3-)
Reactome.org link: R-HSA-9018901