Reaction: ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA
- in pathway: Biosynthesis of aspirin-triggered D-series resolvins
5-lipoxygenase (ALOX5) possesses dual lipoxygenase activity (Shimizu et al. 1984). In polymorphonuclear (PMN) cells, ALOX5 can epoxygenate (via dehydration) 7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid (7(S)-Hp-17(R)-HDHA) to form 7S(8)-epoxy-17(R)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(R)-HDHA (Serhan et al. 2002).
Reaction - small molecule participants:
NADPH [cytosol]
7S(8)-epoxy-17(R)-HDHA [cytosol]
NADP+ [cytosol]
7(S)-Hp-17(R)-HDHA [cytosol]
Reactome.org reaction link: R-HSA-9020256
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Reaction input - small molecules:
NADP(3-)
7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid
Reaction output - small molecules:
NADPH(4-)
7S,8S-epoxy-17R-hydroxydocosahexaenoic acid
Reactome.org link: R-HSA-9020256