Reaction: ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA
- in pathway: Biosynthesis of protectins
The hydroperoxide intermediate of docosahexaenoic acid (17(R)-Hp-DHA) undergoes a second hydrogen abstraction by 15-lipoxygenase (ALOX15) to form the intermediate epoxide 17R(16)-epoxy-DHA (Serhan et al. 2011).
Reaction - small molecule participants:
NADPH [cytosol]
17R(16)-epoxy-DHA [cytosol]
NADP+ [cytosol]
17(R)-Hp-DHA [cytosol]
Reactome.org reaction link: R-HSA-9020262
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Reaction input - small molecules:
NADP(3-)
(4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid
Reaction output - small molecules:
NADPH(4-)
17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid
Reactome.org link: R-HSA-9020262