Reaction: GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA
- in pathway: Biosynthesis of aspirin-triggered D-series resolvins
Cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 17(R)-hydroperoxy-docosahexaenoic acid (17(R)-Hp-DHA) to 17(R)-hydroxydocosahexaenoic acid (17(R)-HDHA) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013). 17(R)-HDHA can then be transformed into 17(R)-D-resolvins and a 17-oxo electrophilic product 17-oxo-DHA (Groeger et al. 2010).
Reaction - small molecule participants:
H2O [cytosol]
17(R)-HDHA [cytosol]
GSSG [cytosol]
GSH [cytosol]
17(R)-Hp-DHA [cytosol]
Reactome.org reaction link: R-HSA-9020271
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Reaction input - small molecules:
glutathionate(1-)
(4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid
Reaction output - small molecules:
water
17(R)-HDoHE
glutathione disulfide(2-)
Reactome.org link: R-HSA-9020271