Reaction: ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA
- in pathway: Biosynthesis of D-series resolvins
5-lipoxygenase (ALOX5) possesses dual lipoxygenase activity (Shimizu et al. 1984). In polymorphonuclear (PMN) cells, ALOX5 can epoxygenate (via dehydration) 4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid (4(S)-Hp-17(S)-HDHA) to form 4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid (4S(5)-epoxy-17(S)-HDHA (Serhan et al. 2002).
Reaction - small molecule participants:
NADPH [cytosol]
4S(5)-epoxy-17(S)-HDHA [cytosol]
NADP+ [cytosol]
4(S)-Hp-17(S)-HDHA [cytosol]
Reactome.org reaction link: R-HSA-9020277
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Reaction input - small molecules:
NADP(3-)
4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid
Reaction output - small molecules:
NADPH(4-)
4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid
Reactome.org link: R-HSA-9020277