Reaction: HIPK2 phosphorylates MECP2
- in pathway: Regulation of MECP2 expression and activity
Nuclear serine/threonine protein kinase HIPK2 phosphorylates MECP2 on serine residue S80 (Bracaglia et al. 2009). Phosphorylation of MECP2 at S80 correlates with low neuronal activity. Upon neuronal activation, calcium influx stimulates dephosphorylation at S80 (Tao et al. 2009).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-9022314
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9022314