Reaction: ALOX15 oxidises 17(S)-Hp-DHA to PDX
- in pathway: Biosynthesis of protectins
15-lipoxygenase (ALOX15) can mediate a second lipoxygenation reaction where 17(S)-Hp-DHA is oxidised to the production of the protectin D1 (PD1) isomer PDX (Hong et al. 2003, Serhan et al. 2006, Chen et al. 2009). The chemical structure of PDX is 10(S),17(S)-dihydroxy-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid. It differs from PD1, having E,Z,E geometry (PDX) instead of E,E,Z (PD1) and S configuration at carbon 10 instead of R (Chen et al. 2009). PDX is not a major product of leukocytes and has low potency compared to PD1 as a regulator of polymorphonuclear leukocyte (PMN) infiltration (Serhan et al. 2006).
Reaction - small molecule participants:
PDX [cytosol]
O2 [cytosol]
17(S)-Hp-DHA [cytosol]
Reactome.org reaction link: R-HSA-9024872
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Reaction input - small molecules:
dioxygen
(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid
Reaction output - small molecules:
(4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid
Reactome.org link: R-HSA-9024872