Reaction: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA
- in pathway: Biosynthesis of DHA-derived SPMs
In macrophages, lipoxygenase 12 (ALOX12:Fe2+) may abstract hydrogen from 14(S)-hydroperoxy-docosaheaenoic acid (14(S)-Hp-DHA) to form 13(S),14(S)-epoxy-DHA (Serhan et al. 2009, Dalli et al. 2013, Deng et al. 2014). This epoxy product is a central intermediate in maresin MaR1 and MaR2 and maresin conjugates in tissue regeneration (MCTR) biosyntheses (Dalli et al. 2016) as well as possessing potent proresolving activity (Dalli et al 2013).
Reaction - small molecule participants:
NADPH [cytosol]
13(S),14(S)-epoxy-DHA [cytosol]
14(S)-Hp-DHA [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-9024983
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Reaction input - small molecules:
(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoic acid
NADP(3-)
Reaction output - small molecules:
NADPH(4-)
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
Reactome.org link: R-HSA-9024983