Reaction: ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3
- in pathway: Biosynthesis of DPAn-3-derived protectins and resolvins
At sites of injury, 15 lipoxygenase (ALOX15) can oxygenate ω-3 docosapentaenoic acid (DPAn-3) to form the 17(S) epimer 17(S)-hydroperoxy docosapentaenoic acid (17(S)-Hp-DPAn-3) in neutrophils (Dalli et al. 2013). The formations of individual hydroperoxy intermediates are supported by chemical synthesis experiments (Aursnes et al. 2014, Primdahl et al. 2017) and are the pivotal intermediates in the production of DPAn-3 derived protectins and resolvins.
Reaction - small molecule participants:
17(S)-Hp-DPAn-3 [cytosol]
DPAn-3 [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9026003
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Reaction input - small molecules:
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate
dioxygen
Reaction output - small molecules:
(7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoic acid
Reactome.org link: R-HSA-9026003