Reaction: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3
- in pathway: Biosynthesis of DPAn-3-derived maresins
In a reaction scheme that could be similar to the one for DHA-derived maresins, a lipoxygenase mediates the abstraction of hydrogen from 14(S)-hydroperoxy-docosapentaenoic acid (14(S)-Hp-DPAn-3) to form the epoxy product 13,14(S)-epoxy-docosapentaenoic acid (13,14(S)-epoxy-DPAn-3) (Dalli et al. 2013). If, as assumed, DPA metabolism follows the same path as for DHA metabolism, the lipoxygenase could be 12-lipoxygenase (ALOX12).
Reaction - small molecule participants:
13,14(S)-epoxy-DPAn-3 [cytosol]
NADPH [cytosol]
14(S)-Hp-DHA [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-9026007
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Reaction input - small molecules:
(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoic acid
NADP(3-)
Reaction output - small molecules:
(7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoic acid
NADPH(4-)
Reactome.org link: R-HSA-9026007