Reaction: NTRK2 activates RAS signaling through SHC1
- in pathway: Activated NTRK2 signals through RAS
SHC1-mediated recruitment of GRB2:SOS1 to the activated NTRK2 (TRKB) receptor leads to activation of RAS signaling and downstream phosphorylation of ERK1 (MAPK3) and ERK2 (MAPK1) (Chan et al. 2001). SOS1 functions as a guanine-nucleotide exchange factor for RAS proteins, catalyzing exchange of GDP for GTP, resulting in formation of the active RAS:GTP complex (Chardin et al. 1993).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9026891
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9026891