Reaction: Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA
- in pathway: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
A lipoxygenase may mediate hydrogen abstraction from 7(S),17(S)-dihydroperoxy-docosahexaenoic acid (7(S),17(S)-diHp-DHA) to form 7S(8)-epoxy-17(S)-hydroxy-docosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) (Dalli et al. 2015). This epoxy intermediate is the precursor for resolvin conjugates in tissue regeneration (RCTR).
Reaction - small molecule participants:
7S(8)-epoxy-17(S)-HDHA [cytosol]
NADPH [cytosol]
7(S),17(S)-diHp-DHA [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-9026917
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Reaction input - small molecules:
(7S,17S)-bis(hydroperoxy)-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid
NADP(3-)
Reaction output - small molecules:
7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid
NADPH(4-)
Reactome.org link: R-HSA-9026917