Reaction: Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA
- in pathway: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
In an alternative route to PCTR production, 17(S)-hydroperoxy-docosahexaenoic acid (17(S)-Hp-DHA) can undergo a second lipoxygenation at carbon 7 position to yield 7S,17S-dihydroperoxy-docosahexaenoic acid (7(S),17(S)-diHp-DHA). A lipoxygenase mediates this reaction although the exact human enzyme is unknown (Dalli et al. 2015).
Reaction - small molecule participants:
7(S),17(S)-diHp-DHA [cytosol]
O2 [cytosol]
17(S)-Hp-DHA [cytosol]
Reactome.org reaction link: R-HSA-9026918
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Reaction input - small molecules:
dioxygen
(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid
Reaction output - small molecules:
(7S,17S)-bis(hydroperoxy)-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid
Reactome.org link: R-HSA-9026918