Reaction: DOCK3 activates RAC1
- in pathway: NTRK2 activates RAC1
DOCK3 activates RAC1 and contributes to recruitment of the RAC1 effector WASF1 (WAVE1). DOCK3-mediated activation of RAC1 is involved in BDNF-induced axonal sprouting (Namekata et al. 2010).
WASF1 has recently been implicated in endocytosis of the BDNF:NTRK2 (BDNF:TRKB) complex (Xu et al. 2016).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9032798
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9032798