Reaction: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
- in pathway: Activated NTRK2 signals through CDK5
TIAM1, activated by binding to CDK5-phosphorylated and BDNF-activated NTRK2 (TRKB), promotes guanine nucleotide exchange on RAC1, which results in formation of the active RAC1:GTP complex (Lai et al. 2012).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9033292
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9033292