Reaction: ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s
- in pathway: GPER1 signaling
Binding of E2 to GPER induces the exchange of GDP for GTP on the G alpha (s) heterotrimer G protein, activating it (Filardo et al, 2007; Thomas et al, 2005; Revankar et al, 2005).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9036301
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9036301