Reaction: NTRK3 activates RAS through SHC1
- in pathway: Activated NTRK3 signals through RAS
Stimulation of NTRK3 (TRKC) by recombinant human NTF3 (NT-3) increases the amount of GTP-bound RAS (Marsh and Palfrey 1996). Activation of RAS targets MAPK3 (ERK1) and MAPK1 (ERK2) was shown to depend on SHC1-mediated recruitment of GRB2 to activated NTRK3 (Gunn-Moore et al. 1997, Yuen and Mobley 1999).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9036970
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9036970