Reaction: PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA
- in pathway: Degradation of GABA
GABA and 2-oxoglutarate (2OG) are converted to succinate semialdehyde (SUCCSA) and L-glutamate (L-Glu) by 4 aminobutyrate aminotransferase (ABAT). The reaction takes place in the mitochondrial matrix. The active form of the enzyme is a dimer, with each subunit associated with a molecule of pyridoxal phosphate (PXLP) (De Biase et al. 1995).
Reaction - small molecule participants:
SUCCSA [mitochondrial matrix]
L-Glu [mitochondrial matrix]
GABA [mitochondrial matrix]
2OG [mitochondrial matrix]
Reactome.org reaction link: R-HSA-916855
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Reaction input - small molecules:
gamma-aminobutyric acid zwitterion
2-oxoglutarate(2-)
Reaction output - small molecules:
4-oxobutanoate
L-glutamate(1-)
Reactome.org link: R-HSA-916855