Reaction: STEAP3-like proteins reduce Fe3+ to Fe2+
- in pathway: Transferrin endocytosis and recycling
The iron ions that are no longer bound to transferrin are reduced by the metalloreductase STEAP3, an endosomal membrane protein. The electron donor partner of the enzyme is unknown (Ohgami et al, 2005; Ohgami et al, 2006).
Reaction - small molecule participants:
Fe2+ [endosome lumen]
e- [endosome membrane]
Fe3+ [endosome lumen]
Reactome.org reaction link: R-HSA-917811
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Reaction input - small molecules:
electron
iron(3+)
Reaction output - small molecules:
iron(2+)
Reactome.org link: R-HSA-917811