Reaction: Acidification of Tf:TfR1 containing endosome
- in pathway: Transferrin endocytosis and recycling
The function of V-type proton pumping ATPases is basically the same as that of F-type ATPases, except that V-ATPases cannot synthesize ATP from the proton motive force, the reverse reaction of pumping. When pumping, ATP hydrolysis drives a 120 degree rotation of the rotor which leads to movement of three protons into the phagosome (Adachi et al. 2007).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H+ [endosome lumen]
H2O [cytosol]
H+ [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-917841
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Reaction input - small molecules:
water
hydron
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
hydron
Reactome.org link: R-HSA-917841