Reaction: MCOLN1 transports Fe2+ from endosome lumen to cytosol
- in pathway: Transferrin endocytosis and recycling
Mucolipin-1 is an iron ion channel specifically expressed in endosome and lysosome membranes. It catalyzes the diffusion of Fe2+ ions into the cytosol (Dong et al, 2008).
Reaction - small molecule participants:
Fe2+ [cytosol]
Fe2+ [endosome lumen]
Reactome.org reaction link: R-HSA-917936
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Reaction input - small molecules:
iron(2+)
Reaction output - small molecules:
iron(2+)
Reactome.org link: R-HSA-917936