Reaction: Cyclisation of GTP to precursor Z
- in pathway: Molybdenum cofactor biosynthesis
GTP cyclizes in a reaction involving radicals of S-adenosylmethionine, catalyzed by the iron-sulfur cluster dimeric MOCS1. The intermediate result is called precursor Z (Hanzelmann et al, 2002; Hanzelmann et al, 2004).
Reaction - small molecule participants:
PPi [cytosol]
Precursor Z [cytosol]
dADE [cytosol]
L-Met [cytosol]
GTP [cytosol]
H2O [cytosol]
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-947535
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Reaction input - small molecules:
GTP(4-)
water
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
diphosphate(3-)
precursor Z(1-)
5'-deoxyadenosine
L-methionine zwitterion
Reactome.org link: R-HSA-947535