Reaction: p-S516-ARHGEF7 activates RAC1
- in pathway: Activation of RAC1 downstream of NMDARs
CAMK1-mediated phosphorylation of ARHGEF7 (Beta-Pix) at serine S516 enhances guanine nucleotide exchange factor (GEF) activity of ARHGEF7, leading to RAC1 activation. RAC1 and its downstream effector PAK1 are involved in NMDA receptor activity-dependent synaptogenesis (Saneyoshi et al. 2013).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9619803
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9619803