Reaction: RCC1 stimulates GDP to GTP exchange on RAN
- in pathway: Postmitotic nuclear pore complex (NPC) reformation
Chromatin-associated RCC1 mediates GDP to GTP exchange on RAN, resulting in formation of the active RAN:GTP complex (Hetzer et al. 2000, reviewed by Zierhut and Funabiki 2015). The high concentration of RAN:GTP near chromatin promotes multiple aspects of nuclear envelope reassembly (reviewed by Forbes et al. 2015). RAN:GDP may be involved in recruitment of RCC1 to chromatin (Zhang et al. 2002).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9624845
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9624845