Reaction: S1P binds S1PR3 in response to E2 stimulation
- in pathway: Extra-nuclear estrogen signaling
S1P binds to its GPCR receptor S1PR3 downstream of E2 stimulation and GPER1 (Sukocheva et al, 2003; Sukocheva et al, 2006). S1P-bound S1PR3 promotes transactivation of the EGFR signaling pathway through the MMP-dependent liberation of HBEGF from the plasma membrane, leading to EGFR and MAPK phosphorylation (Sukocheva et al, 2003; Sukocheva et al, 2006; Kim et al, 2000; Tanimoto et al, 2004; Filardo et al, 2000; Razandi et al, 2003).
Reaction - small molecule participants:
S1P [plasma membrane]
Reactome.org reaction link: R-HSA-9625813
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Reaction input - small molecules:
sphingosine 1-phosphate(1-)
Reaction output - small molecules:
Reactome.org link: R-HSA-9625813