Reaction: JMJD7 dimer hydroxlates a lysine residue of DRG1
- in pathway: Protein hydroxylation
JMJD7 (JmjC domain-containing protein 7) catalyzes the 3-hydroxlation of a lysine residue of DRG1 (developmentally-regulated GTP-binding protein 1). The catalytically active form of JMJD7 is a dimer, each monomeric subunit of which is associated with a Fe2+ ion (Markolovic et al. 2018). DRG1 occurs as a heterdimer with one molecule of ZC3H15 (DFRP1) (Ishikawa et al. 2005, 2009).
Reaction - small molecule participants:
SUCCA [cytosol]
CO2 [cytosol]
2OG [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9629591
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
succinate(2-)
carbon dioxide
Reactome.org link: R-HSA-9629591