Reaction: JMJD4:Fe2+ hydroxylates a lysine residue of ETF1
- in pathway: Protein hydroxylation
Cytosolic JMJD4 (JmjC domain-containing protein 4) catalyzes the 4-hydroxlation of lysine-63 residue of ETF1 (eukaryotic peptide chain release factor subunit 1, also known as eRF1). This hydroxylation substantially increases the efficiency with which ETF1 recognizes stop codons (Feng et al. 2014). The catalytically active form of JMJD4 is associated with a Fe2+ ion.
Reaction - small molecule participants:
SUCCA [cytosol]
CO2 [cytosol]
2OG [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9629946
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
succinate(2-)
carbon dioxide
Reactome.org link: R-HSA-9629946