Reaction: JMJD6 dimer hydroxylates lysine residues of U2AF2
- in pathway: Protein hydroxylation
Nuclear JMJD6 (JmjC domain-containing protein 6) catalyzes the hydroxylation of the 5-carbons of two lysine residues of U2AF2 (splicing factor U2AF 65 kDa subunit, also known as U2AF65) (Webby et al. 2009; Unoki et al. 2013). The active form of the protein is associated with Fe2+. The protein crystallizes as dimers (Mantri et al. 2010) and can form larger oligomers in solution (Hahn et al. 2010). For simplicity, the active form of the enzyme is annotated here as a dimer.
JMJD6 has also been reported to have histone demethylase activity (Chang et al. 2007). This activity has been annotated as part of Reactome pathway R-HSA-321842 "HDMs demethylate histones".
Reaction - small molecule participants:
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-9630022
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-9630022