Reaction: OGFOD1:Fe2+ hydroxylates a proline residue of RPS23
- in pathway: Protein hydroxylation
OGFOD1 (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) catalyzes the 3-hydroxylation of proline residue 62 of RPS23 (40S ribosomal protein S23) (Loenarz et al. 2014; Singleton et al. 2014). The active form of the enzyme is a monomer complexed with Fe2+ (Horita et al. 2015). Its nuclear localization is inferred from studies of the closely homologous Drosophila protein (Katz et al 2014).
Reaction - small molecule participants:
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-9630769
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-9630769