Reaction: RIOX2Fe2+ hydroxylates a histidine residue of RPL27A
- in pathway: Protein hydroxylation
Nuclear RIOX2 (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) 3-hydroxylates histidine 39 of RPL27A (60S ribosomal protein L27a) (Ge et al. 2012). The oligomerization state of RIOX2 in vivo is unknown; it is annotated here as a monomer complexed with one Fe2+ ion (Brauer et al. 2018).
Reaction - small molecule participants:
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-9630967
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-9630967