Reaction: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1
- in pathway: Constitutive Signaling by Overexpressed ERBB2
Based on activation of RAS signaling by autophosphorylated ERBB2 homodimers, as well as binding of GRB2 and SHC1 to ERBB2 homodimers (Pickl and Ries 2009), it is assumed that SOS1, recruited to ERBB2 homodimers through GRB2, mediates GDP to GTP exchange on RAS protein family, resulting in formation of the active RAS:GTP complex.
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9634418
======
Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9634418