Reaction: RRAGC,D exchanges GTP for GDP
- in pathway: Amino acids regulate mTORC1
The Ragulator complex acts as an unconventional guanyl nucleotide exchange factor (GEF) that ejects GTP from RRAGC and, by inference, RRAGD (Shen and Sabatini 2018). (Other known GEFs cause ejection of GDP rather than GTP from their targets.) The GDP-bound form of RRAGC,D is the active form that recruits mTORC1 to the lysosomal membrane.
Reaction - small molecule participants:
GTP [cytosol]
GDP [cytosol]
Reactome.org reaction link: R-HSA-9639286
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Reaction input - small molecules:
GDP(3-)
Reaction output - small molecules:
GTP(4-)
Reactome.org link: R-HSA-9639286