Reaction: FLVCR1-2 transports heme from mitochondrial matrix to cytosol
- in pathway: Heme biosynthesis
Feline leukemia virus subgroup C receptor-related protein 1 isoform 2 (FLVCR1-2), located on the mitochondrial membrane of all hematopoietic tissues, is a heme transporter that mediates heme efflux from the mitochondrion to the cytosol (Chiabrando et al. 2012). Silencing of FLVCR1-2 causes mitochondrial heme accumulation and termination of erythroid differentiation.
Reaction - small molecule participants:
heme [cytosol]
heme [mitochondrial matrix]
Reactome.org reaction link: R-HSA-9661408
======
Reaction input - small molecules:
ferroheme b
Reaction output - small molecules:
ferroheme b
Reactome.org link: R-HSA-9661408