Reaction: KIT mutants:PI3K catalyze synthesis of PIP3
- in pathway: Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
PI3K/AKT signaling is initiated downstream of KIT juxtamembrane and kinase domain mutants, as assessed by the presence of phosphorylated AKT in Western analysis (Kemmer et al, 2004; Nakai et al, 2005; Duensing et al, 2004; Tarn et al, 2006; Rossi et al, 2006; Bauer et al, 2007; Bosbach et al, 2017; Zhu et sl, 2007; Serrano et al, 2019; reviewed in Lennartsson and Roonstrand, 2012).
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
ADP [cytosol]
ATP [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-9670433
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ADP(3-)
Reactome.org link: R-HSA-9670433