Reaction: PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers
- in pathway: Signaling by PDGFRA extracellular domain mutants
Gain-of-function extracellular domain mutants of PDGFRA signal through the PI3K/AKT signaling pathway as assessed by the increase in phosphorylated AKT, although all the pathway steps have not been directly demonstrated (Ozawa et al, 2010; Ip et al, 2018).
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
ADP [cytosol]
ATP [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-9672162
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ADP(3-)
Reactome.org link: R-HSA-9672162