Reaction: SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers
- in pathway: Signaling by PDGFRA extracellular domain mutants
SOS-mediated nucleotide exchange on RAS is likely promoted by extracellular domain mutants of PDGFRA, as evidenced by the increased levels of phosphorylated MAPK/ERK proteins, although the details have not been fully demonstrated (Ozawa et al, 2010; Ip et al, 2018).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9672163
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9672163