Reaction: SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
SOS-mediated exchange of GTP for GDP on RAS is predicted to be stimulated by gain-of-function PDGFRA mutants, based on the increased levels of phosphorylated MAPK3 and MAPK1 proteins (ERK1 and ERK2, respectively) (Heinrich et al, 2003; Corless et al, 2005; Ohashi et al, 2004; Velghe et al, 2014; reviewed in Corless et al, 2011; Roskoski, 2018).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9672170
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9672170